Publications

Systemic Immunity Is Required for Effective Cancer Immunotherapy.
Spitzer MH, Carmi Y, Reticker-Flynn NE, Kwek SS, Madhireddy D, Martins MM, Gherardini PF, Prestwood TR, Chabon J, Bendall SC, Fong L, Nolan GP, Engleman EG.
Cell. 2017 Jan 10. pii: S0092-8674(16)31738-X. doi: 10.1016/j.cell.2016.12.022. [Epub ahead of print]
PMID: 28111070
 
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.
Furman D, Chang J, Lartigue L, Bolen CR, Haddad F, Gaudilliere B, Ganio EA, Fragiadakis GK, Spitzer MH, Douchet I, Daburon S, Moreau JF, Nolan GP, Blanco P, Déchanet-Merville J, Dekker CL, Jojic V, Kuo CJ, Davis MM, Faustin B.
Nat Med. 2017 Jan 16. doi: 10.1038/nm.4267.
 
Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity.
Carmi Y, Prestwood TR, Spitzer MH, Linde IL, Chabon J, Reticker-Flynn NE, Bhattacharya N, Zhang H, Zhang X, Basto PA, Burt BM, Alonso MN, Engleman EG.
JCI Insight. 2016 Nov 3;1(18):e89020.
PMID: 27812544
 
Mapping the Fetomaternal Peripheral Immune System at Term Pregnancy.
Fragiadakis GK, Baca QJ, Gherardini PF, Ganio EA, Gaudilliere DK, Tingle M, Lancero HL, McNeil LS, Spitzer MH, Wong RJ, Shaw GM, Darmstadt GL, Sylvester KG, Winn VD, Carvalho B, Lewis DB, Stevenson DK, Nolan GP, Aghaeepour N, Angst MS, Gaudilliere BL. 
J Immunol. 2016 Oct 28. pii: 1601195.
PMID: 27793998
 
Automated mapping of phenotype space with single-cell data.
Samusik N, Good Z, Spitzer MH, Davis KL, Nolan GP.
Nat Methods. 2016 Jun;13(6):493-6. doi: 10.1038/nmeth.3863. Epub 2016 May 16.
PMID: 27183440
 
Mass Cytometry: Single Cells, Many Features.
Spitzer MH, Nolan GP.
Cell. 2016 May 5;165(4):780-91. doi: 10.1016/j.cell.2016.04.019. Review.
PMID: 27153492
 
An interactive reference framework for modeling a dynamic immune system.
Spitzer MH, Gherardini PF, Fragiadakis GK, Bhattacharya N, Yuan RT, Hotson AN, Finck R, Carmi Y, Zunder ER, Fantl WJ, Bendall SC, Engleman EG, Nolan GP.
Science. 2015 Jul 10;349(6244):1259425. doi: 10.1126/science.1259425.
PMID: 26160952
 
Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity.
Carmi Y, Spitzer MH, Linde IL, Burt BM, Prestwood TR, Perlman N, Davidson MG, Kenkel JA, Segal E, Pusapati GV, Bhattacharya N, Engleman EG.
Nature. 2015 May 7;521(7550):99-104. doi: 10.1038/nature14424. Epub 2015 Apr 29.
PMID: 25924063
 
Palladium-based mass tag cell barcoding with a doublet-filtering scheme and single-cell deconvolution algorithm.
Zunder ER, Finck R, Behbehani GK, Amir el-AD, Krishnaswamy S, Gonzalez VD, Lorang CG, Bjornson Z, Spitzer MH, Bodenmiller B, Fantl WJ, Pe'er D, Nolan GP.
Nat Protoc. 2015 Feb;10(2):316-33. doi: 10.1038/nprot.2015.020. Epub 2015 Jan 22.
PMID: 25612231
 
Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice.
Mingueneau M, Krishnaswamy S, Spitzer MH, Bendall SC, Stone EL, Hedrick SM, Pe'er D, Mathis D, Nolan GP, Benoist C.
Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16466-71. doi: 10.1073/pnas.1419337111. Epub 2014 Oct 31.
PMID: 25362052
 
Systems biology. Conditional density-based analysis of T cell signaling in single-cell data.
Krishnaswamy S, Spitzer MH, Mingueneau M, Bendall SC, Litvin O, Stone E, Pe'er D, Nolan GP.
Science. 2014 Nov 28;346(6213):1250689. doi: 10.1126/science.1250689. Epub 2014 Oct 23.
PMID: 25342659
 
A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras-mediated spinogenesis.
Megill A, Lee T, DiBattista AM, Song JM, Spitzer MH, Rubinshtein M, Habib LK, Capule CC, Mayer M, Turner RS, Kirkwood A, Yang J, Pak DT, Lee HK, Hoe HS.
J Neurosci. 2013 May 29;33(22):9306-18. doi: 10.1523/JNEUROSCI.1615-12.2013. Erratum in: J Neurosci. 2014 Oct 1;34(40):13567. 
PMID: 23719799
 
The transcriptional landscape of αβ T cell differentiation.
Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C; Immunological Genome Consortium.
Nat Immunol. 2013 Jun;14(6):619-32. doi: 10.1038/ni.2590. Epub 2013 May 5.
PMID: 23644507